ABSTRACT
Between 8 August and 9 October 2005, tropical Singapore experienced a national epidemic of acute viral conjunctivitis. We report the epidemiological and virological findings of outbreaks of viral conjunctivitis in military facilities during the same time period, and the outbreak control measures taken. Outbreaks of viral conjunctivitis were identified by medical officers in military medical facilities. Epidemiological and virological investigations were carried out, and a standard set of control measures was instituted for each outbreak upon detection. Eight outbreaks of viral conjunctivitis occurred in the time period, corresponding to the national outbreak. Delayed detection and institution of preventive measures during the outbreaks were associated with delayed effectiveness of the control measures. Every delay in outbreak detection by one day resulted in a delay in terminating the outbreak by 0.82 days (p = 0.01). Coxsackievirus A24 was identified from some of the conjunctival swab samples taken.
Subject(s)
Conjunctivitis, Acute Hemorrhagic/epidemiology , Disease Outbreaks/prevention & control , Enterovirus/isolation & purification , Enterovirus Infections/epidemiology , Humans , Incidence , Military Personnel , Singapore/epidemiologyABSTRACT
PURPOSE: To document etiology and predictive value of clinical diagnosis in laboratory confirmed viral diseases. METHODS: Reports of culture-positive cases of samples collected from patients presenting from January 1987 - December 2001 were evaluated. RESULTS: One thousand nine hundred and sixty-four (1964) cultures were submitted during 1987-2001. Twenty-six percent were positive (514). Human herpesvirus 1 was the most frequent agent isolated from all positive culture (56 percent). Adenovirus was the most common virus isolated from conjunctiva (66 percent), human herpesvirus 1 from lid and cornea (76 percent, 88 percent) and cytomegalovirus from vitreous (27 percent). Some unusual pathogens were recovered from conjunctiva as cytomegalovirus and from cornea as adenovirus, enterovirus and cytomegalovirus. Recognition of common viral syndromes was human herpesvirus 1 (88 percent), epidemic keratoconjunctivitis (88 percent), acute hemorrhagic conjunctivitis (70 percent) and varicella zoster virus (100 percent). However, some misdiagnosed cases were observed. Thirteen percent of conjunctivitis thought to be caused by herpes were due to adenovirus, 3.2 percent to Enterovirus, 3.2 percent to varicella zoster virus and 3.2 percent to human cytomegalovirus. Also, 5 percent of cases with a clinical diagnosis of herpes keratitis were caused by adenovirus and 2.7 percent by enterovirus. Finally, 4.8 percent of cases thought to be adenovirus conjunctivitis were herpes conjunctivitis. CONCLUSIONS: Human herpesvirus 1 remains the most frequently isolated virus from ocular sites in general (56 percent). Nonherpetic corneal isolates were in decreasing order: adenovirus, enterovirus and cytomegalovirus. Clinical and laboratory correlation was less than 90 percent. The most misdiagnosed cases were herpes conjunctivitis and keratitis, some cases of adenovirus conjunctivitis some cases of acute hemorrhagic conjunctivitis. It is essential that a rapid and...
OBJETIVOS: Documentar a etiologia e prever a importância do diagnóstico clínico em doenças virais oculares confirmadas em laboratório. MÉTODOS: Todos os relatórios de pacientes com cultura viral positiva durante o período de janeiro 1987 - dezembro 2001 foram analisados. RESULTADOS: Quinhentos e quatorze (514) casos foram encontrados. Em geral, herpesvírus 1 humano foi o agente mais freqüentemente isolado. Adenovírus foi o vírus mais comumente isolado da conjuntiva (66 por cento), herpesvírus 1 humano das pálpebras e córnea (76 por cento, 88 por cento respectivamente) e citomegalovírus do vítreo (27 por cento). Alguns agentes não usuais foram isolados da conjuntiva como citomegalovírus e da córnea como adenovírus, enterovírus e citomegalovírus. Reconhecimento das síndromes virais comuns foi: herpervírus 1 humano (88 por cento), ceratoconjuntivite epidêmica (88 por cento), conjuntivite aguda hemorrágica (70 por cento). Porém, alguns casos com diagnóstico incorreto foram observados. Treze por cento das conjuntivites com diagnóstico de herpes foram causadas por adenovírus, 3,2 por cento por enterovírus, 3,2 por cento por varicella zoster vírus e 3,2 por cento por citomegalovírus. Também, 5 por cento dos casos com diagnóstico clínico de ceratite herpética eram adenovírus e 2,7 por cento enterovírus. Além disso, 4,8 por cento dos casos em que se pensaram em conjuntivite por adenovírus, eram conjuntivite por herpes. Finalmente, 30 por cento dos casos em que se diagnosticaram conjuntive hemorrágica aguda, o agente etiológico era adenovírus. CONCLUSÃO: Em geral herpesvírus humano 1 continua a ser o vírus mais comum encontrado nas infecções oculares (56 por cento). Agentes não herpéticos isolados da córnea foram em ordem decrescente: adenovírus, enterovírus e citomegalovírus. A correlação entre o diagnóstico clínico e laboratorial foi menor do que 90 por cento. Um diagnóstico rápido e específico é essencial em casos de apresentações virais atípicas...
Subject(s)
Humans , Eye Infections, Viral/diagnosis , Eye Infections, Viral/etiology , Keratoconjunctivitis/diagnosis , Keratoconjunctivitis/etiology , Brazil/epidemiology , Clinical Laboratory Techniques , Conjunctivitis, Acute Hemorrhagic/diagnosis , Conjunctivitis, Acute Hemorrhagic/epidemiology , Conjunctivitis, Acute Hemorrhagic/etiology , Cornea/virology , DNA Viruses/isolation & purification , Diagnostic Errors/prevention & control , Enterovirus/isolation & purification , Eye Infections, Viral/epidemiology , False Positive Reactions , Herpes Zoster/virology , Keratoconjunctivitis/epidemiology , Predictive Value of Tests , Seasons , Time Factors , Virus CultivationABSTRACT
A nationwide outbreak of acute hemorrhagic conjunctivitis (AHC) occurred in Nepal during August to September 2003, which affected nearly half of the population. Sixty conjunctival swabs from AHC patients were collected at Tilganga Eye Center in Kathmandu. For the first time in Nepal, we demonstrated the etiologic viral agents of AHC, namely, Coxsackievirus A24 variant (CA24v) by reverse transcription real time polymerase chain reaction (PCR). Of the 60 samples, 19 were positive for CA24v. No difference in the two genders was observed. Conversely, Adenovirus (AdV) was detected in 32 samples, which suggested that the epidemic was caused by mixed infection. AdV was detected also on 10 rupee notes. Findings indicated that inadequate personal hygiene was the main cause of the spread of these highly contagious viruses in the community environment in Nepal during the summer of 2003.
Subject(s)
Adenoviridae/isolation & purification , Adenoviridae Infections/complications , Adolescent , Adult , Child , Child, Preschool , Conjunctivitis, Acute Hemorrhagic/epidemiology , Coxsackievirus Infections/complications , Disease Outbreaks , Enterovirus C, Human/isolation & purification , Female , Humans , Infant , Infant, Newborn , Male , Middle Aged , Nepal/epidemiology , Reverse Transcriptase Polymerase Chain ReactionABSTRACT
This rapid communication present the findings of nationwide outbreak of acute hemorrhagic conjunctivitis (AHC) epidemic occurred in Nepal during summer 2003. Only ten percent of samples showed bacterial and no fungus were grown. On the contrary, viruses were detected in 60.0% cases studied. Of the viruses detected, Adenovirus (ADV), Coxsackie virus (CA24v) and both accounted for 83.3% (30/36), 11.1% (4/36) and 5.5% (2/36), respectively. Interestingly, ADV was detected also from one of the ten a Rupees bill.
Subject(s)
Adenovirus Infections, Human/epidemiology , Conjunctivitis, Acute Hemorrhagic/epidemiology , Coxsackievirus Infections/epidemiology , Disease Outbreaks , Humans , Nepal/epidemiologyABSTRACT
OBJECTIVE: To clinically analyze 400 cases of red eye attending Nepal Eye Hospital in August/ September 2003 and to study the aetiology of the disease on the clinical basis with available laboratory resources. MATERIALS AND METHODS: It is a prospective study of 400 cases of acute conjunctivitis visiting Nepal Eye Hospital during the epidemic of acute haemorrhagic conjunctivitis in August/September 2003. RESULT: 30.5% presented in the age group of 20-29 years. Males presented predominantly (73.3%). Maximum number of patients presented at two days of onset of symptoms. All 400 cases had red eye, 89.8% had pain, 86.3% had foreign body sensation and 87.5% had discharge. Bilateral involvement was seen in 73.5% and unilateral involvement in 26.5%, 4.3 % of the total cases had corneal involvement and 20% of the cases had associated fever and preauricular lymphadenopathy. CONCLUSION: Based on clinical presentation and the report of available laboratory results, picorna virus was found to be responsible for this epidemic of acute haemorrhagic conjunctivitis.
Subject(s)
Adolescent , Adult , Age Distribution , Aged , Child , Child, Preschool , Conjunctivitis, Acute Hemorrhagic/epidemiology , Disease Outbreaks , Female , Humans , Infant , Male , Middle Aged , Nepal/epidemiology , Picornaviridae Infections/epidemiology , Seasons , Sex DistributionABSTRACT
BACKGROUND & OBJECTIVES: An epidemic of acute haemorrhagic conjunctivitis (AHC) occurred in north India during July to September 1994. We report a reverse transcription-polymerase chain reaction (RT-PCR) using known and novel primers to differentiate and identify the CA 24 virus isolated from the epidemic of AHC. METHODS: Conjunctival swabs were collected from 46 patients (in 12 patients from both the eyes) yielding 58 swabs. The swabs were inoculated in RD 19S and HeLa-199 cell monolayers and observed for cytopathic effect. Serum neutralizing antibodies were tested in 17 acute and 10 convalescent phase serum samples. RT-PCR was done on 9 isolates (7 Coxsackie A 24 and 2 ECHO-1 as identified by neutralization test) using known and a novel primer. Fourteen virus isolates (9 CA 24, 3 ECHO-1 and 2 untyped) were inoculated in suckling mice and these mice were observed daily for 10 days for flaccid paralysis of hind limb or death. RESULTS: Cytopathic virus was isolated from conjunctival swabs in 21 of 46 (45.6%) patients subjected to virus isolation. Sixteen of 21 (76.2%) isolates were neutralized by CA 24 specific antisera, 3 isolates were identified as ECHO-1 with Schmidt enteroviruses antiserum pools while 2 remained untypable. Of these 21 isolates, 9 representative isolates (7 CA 24 and 2 ECHO-1) tested by RT-PCR had enterovirus common region DNA but did not show any amplification in RT-PCR with EV-70 specific primers (VP-1 and VP-3). Using CA 24 specific novel (VP 3-1) primers amplification was seen in 6 of 7 CA 24 isolates while 2 ECHO-1 remained unamplified. In contrast with 3C-proteinase region primers, only 2 of 7 CA 24 were amplified along with false amplification of both ECHO-1. Serum neutralizing antibodies were seen in 2 of 17 (11.7%) acute phase sera and 6 of the 10 (60%) convalescent phase sera while in paired sera (available in two patients) a four-fold rise in titres were observed. Hind-limb paralysis and/or death occurred in all suckling mice inoculated with CA 24 isolates while mice remained healthy after inoculation with 3 isolates of ECHO-1 and 2 untypable isolates. INTERPRETATION & CONCLUSION: The epidemic of AHC was caused by a variant of CA 24. Molecular typing can detect and differentiate between CA 24 and EV-70 viruses. Novel primer pair was found useful in the identification and confirmation of CA 24 isolates.
Subject(s)
Adolescent , Adult , Aged , Animals , Cell Line , Child , Child, Preschool , Conjunctivitis, Acute Hemorrhagic/epidemiology , Coxsackievirus Infections/epidemiology , DNA Primers , Disease Outbreaks , Enterovirus C, Human/classification , Female , Humans , India/epidemiology , Male , Mice , Middle Aged , Neutralization Tests , Reverse Transcriptase Polymerase Chain ReactionABSTRACT
Este estudio presenta la evidencia clínica y serológica de la epidemia de conjuntivitis hemorrágica aguda (CHA) que ocurrió en Puriscal, entre de 1981 y 1982 además de presentar la epidemiología en los años siguientes a su primera aparición y se discute sobre el origen del enterovirus 70, el agente etiológico más frecuente de esta entidad clínica. Las características clínicas encontradas fueron similares a otros estudios. En todas las personas estudiadas, al igual que en el personal de campo y de laboratorio, se detectó seroconversión, e infección subclínica. Seis meses después del primer caso de CHA, se determinó un 43 por ciento de seropositividad en 100 sueros recolectados de la población general en Puriscal. Esta virosis se presenta en forma endémica en Costa Rica, presentándose los picos endememicos cada dos o tres años, con una estacionalidad marcada en los meses de octubre, noviembre y diciembre. Existen varias posiblidades sobre el origen del enterovirus 70; uno de ellas es que el virus se haya derivado de algún otro enterovirus humano que afecte la conjuntiva, o pudo haber existido como una forma no patogénica. También se ha sugerido que el EV-70 pudo haberse derivado de un picornavirus de un invertebrado con un insecto, ya que este virus tiene diferencias muy importantes con el resto de los enterovirus humanos. Hasta el momento no hay evidencia para probar ninguna de estas posibilidades, pero en todo caso, el virus tuvo que haber sufrido una mutación para adquirir la patogenicidad en humanos. Estudios filogénticos han demostrado que el enterovirus 70 se origina de un ancestro común y en la actualidad circulan diferentes cepas que varían antigénicamente entre sí. Palabras claves: Conjunivitis hemorrágica aguda, Enterovirus 70, endémico y estacional, Costa Rica, zoonosis.
Subject(s)
Humans , Conjunctivitis, Acute Hemorrhagic/diagnosis , Conjunctivitis, Acute Hemorrhagic/epidemiology , Conjunctivitis, Acute Hemorrhagic/etiology , Enterovirus , Enterovirus Infections , Costa RicaABSTRACT
An epidemic of acute haemorrhagic conjunctivitis (AHC) was reported from Pune in August-September, 1996. Conjunctival swabs and scrapings were taken from acute patients attending the OPD of the Ophthalmology department of B. J. Medical College, Pune. Conjunctival swabs were processed in human embryonic lung fibroblasts (HEL) cell line and viral isolates were obtained which were identified as Enterovirus (EV) 70 prime strain using standard in-vitro neutralisation test. Indirect intracellular immunofluorescence test also confirmed the identity of the virus involved in the epidemic.
Subject(s)
Conjunctivitis, Acute Hemorrhagic/epidemiology , Humans , India/epidemiologyABSTRACT
El propósito del presente trabajo fue determinar las características clínicas, epidemiológicas y de diagnóstico etiológico de la epidemia de Conjuntivitis Hemorrágica Aguda (CHA) que afectó a 714 personas entre personal asistencial y administrativo del Hospital Nacional Edgardo Rebliati Martins, en Lima, Perú, durante los meses de enero a marzo de 1998, en asociación con el Fenómeno del Niño, el cual es considerado como el sistema de variación climática más prominente, asociado con eventos extremos. El estudio realizado fue de tipo transversal, observacional, teniendo como criterio de exclusión el uso previo de automedicación, quedando un grupo de 50 pacientes, a los que se les realiza un estudio clínico y se procede a la detección del agente etiológico. Mediante pruebas de laboratorio. Se determinó que el periodo de incubación era de 24 a 48 horas con un pico máximo de 24 horas en el 90 por ciento. Los síntomas más frecuentes fueron: ardor 86 por ciento, dolor 74 por ciento, fotofobia 54 por ciento y prurito 32 por ciento. Los signos más frecuentes fueron: secreción conjuntival 100 por ciento, reacción folicular 100 por ciento y hemorragia subconjuntival 95 por ciento. Los síntomas remitieron, con resolución total al 5º día en el 95 por ciento. Los grupos laborales afectados fueron: técnicos de enfermería 44 por ciento, enfermeros 30 por ciento, personal administrativo 8 por ciento, médicos 6 por ciento y otros 12 por ciento. Los cultivos celulares en HEP-2 Ca.de laringe, dieron 41 por ciento de efecto citopático positivo a enterovirus, que al tipificarse mediante inmunofluorescencia indirecta, dio como resultado, ENTEROVIRUS 70 como agente etiológico de esta epidemia de CHA. En los exámenes de laboratorio no se encontraron hongos ni gérmenes comunes, requiriendo solo tratamiento sintomático y control de su diseminación especialmente en los hospitales y durante alteraciones climáticas severas como el fenómeno "El Niño". Palabras clave: Conjuntivitis Hemorrágica Aguda; Epidemia; Infecciones por enterovirus; Epidemiología - Perú. Infecciones Intrahospitalaria, Fenómeno "El Niño".
Subject(s)
Conjunctivitis, Acute Hemorrhagic/epidemiology , Conjunctivitis, Acute Hemorrhagic/etiology , Cross Infection , Enterovirus Infections/etiology , Cross-Sectional StudiesABSTRACT
An epidemic of acute haemorrhagic conjunctivitis affecting persons of all ages and both sexes occurred in Delhi and surrounding areas during the monsoon season of 1994. The symptoms lasted on an average for 4-5 days. In some of the patients corneal involvement was observed. Conjunctival swabs from the affected patients were processed for viral antigen detection, virus isolation and bacterial culture and sensitivity. Viral antigen was detected in 62% (31/50) of the smears tested by indirect immunofluorescence assay. In 22 (44%) of the specimens Coxackie A 24 (Cox A 24) virus antigen and in 9 (18%) of the specimens Entero Virus 70 (EV 70) antigen were detected. In confluent monolayers of Hep 2 cells cytopathic virus was isolated in 10 (30.30%) of the 33 specimens processed. The isolated viruses were identified as either Cox A 24 (7 isolates) or EV 70 (3 isolates) using indirect immunofluorescence assay. Super added bacterial infection was observed in 33% (89/270) of the cases, Staphylococcus albus being the predominant bacteria isolated.
Subject(s)
Antigens, Viral/analysis , Conjunctiva/microbiology , Conjunctivitis, Acute Hemorrhagic/epidemiology , Cornea/microbiology , Coxsackievirus Infections/epidemiology , Disease Outbreaks , Enterovirus/immunology , Enterovirus Infections/epidemiology , Female , Fluorescent Antibody Technique, Indirect , Humans , India/epidemiology , Male , Microbial Sensitivity Tests , Retrospective Studies , Staphylococcal Infections/epidemiology , Staphylococcus aureus/isolation & purificationABSTRACT
Se investigó el agente causal de un brote de conjuntivitis hemorrágica mediante el estudio de 18 exudados conjuntivales, utilizando la técnica de inmunofluorescencia indirecta y el aislamiento en cultivo celular de fibroblastos de embrión humano. Además, se investigaron 395 sueros pareados y se determinó como responsable al Enterovirus 70
Subject(s)
Cells, Cultured , Conjunctivitis, Acute Hemorrhagic/diagnosis , Conjunctivitis, Acute Hemorrhagic/epidemiology , Embryonic Structures , Enterovirus/pathogenicity , Fibroblasts/cytology , Fluorescent Antibody Technique , In Vitro TechniquesABSTRACT
Se realizó un estudio observacional y transversal acerca del comportamiento epidemiológico de la conjuntivitis epidémica vírica en el área metropolitana de San Pedro de Macorís, República Dominicana, durante el período septiembre - diciembre de 1986. El estudio consistió en la realización de una encuesta entre las viviendas de diez sectores seleccionados de la ciudad. Se tomaron 100 viviendas de cada sector mediante muestreo no probabilístico. Durante el último cuatrimestre de 1986 fueron visitadas mil viviendas con una población total de 4 mil 454 personas; de éstas el 66% padeció la enfermedad. El 61,3% presentó conjuntivitis epidémica viral y el resto conjuntivitis bacteriana. El 89% de los casos no recibió tratamiento médico; el barrio Sarmiento resultó el más afectado. En función de nuestro resultado recomendamos medidas preventivas generales
Subject(s)
Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Conjunctivitis, Acute Hemorrhagic/epidemiology , Sex Factors , Cross-Sectional Studies , Educational Status , Housing , Occupations , Conjunctivitis, Acute Hemorrhagic/prevention & control , Age Factors , Dominican Republic/epidemiologyABSTRACT
Säo apresentados os resultados dos estudos sobre o comportamento do Enterovirus-70 (EV-70) na regiäo metropolitana de Säo Paulo desde sua provável introduçäo no veräo de 1984, determinando extensa de conjuntivite hemorrágica aguda (C.H.A.), até o final de 1987 abrangendo preríodo em que este agravo foi pouco notado. Na fase epidêmica ocorrida no primeiro trimestre de 1984 foram estudados 291 indivíduos divididos em três grupos denominados A, B e C, o primeiro formado por pessoas atingidas pela C.H.A. e os outros dois por indivíduos näo atingidos por este agravo mas que, respectivamente, referiam contato domiciliar com casos de C.H.A. e os que näo referiam o citado contato. A demonstraçäo de anticorpos se fez pela técnica de imunofluorescência (IFI) para detectar IgM específico para EV-70 e pela prova de neutralizaçäo em cultura de células BHK-21. Verificou-se que 56,7%,33,3%e 20,6% dos indivíduos pertencentes, respectivamente, aos grupos A,B e C apresentavam anticorpos específicos da classe IgM. No grupo A a faixa etária mais atingida foi a de 10 a 29 anos. No período que vai do fim da primeira e única epidemia até o final de 1987, identificaram-se três casos esporádicos de C.H.A. e 10 pacientes com afecçäo neurológica aguda associada à infecçäo recente pelo EV-70. Nove, destes 10 casos, apresentaram paralisia de nervos cranianos, todos evoluindo sem sequelas clinicamente discerníveis. As formas assintomáticas e os casos esporádicos de C.H.A. e de afecçoes neurológicas mantiveram a circulaçäo do EV-70 no período epidêmico
Subject(s)
Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Conjunctivitis, Acute Hemorrhagic/epidemiology , Enterovirus Infections/epidemiology , Enterovirus/pathogenicity , Antibodies, Viral/analysis , Brazil/epidemiology , Central Nervous System Diseases/etiology , Enterovirus Infections/complications , Enterovirus/immunology , Fluorescent Antibody Technique , Immunoglobulin M/analysis , Neutralization TestsABSTRACT
Se realiza un estudio de un brote de conjuntivitis hemorrágica aguda epidérmica en la ciudad costera de Bluefields, ocurrido durante los meses de abril-junio de 1987. Se estudia la distribución del universo (619 pacientes) por edad, sexo y áreas geográficas de procedencia. Se estudiaron, además, 300 pacientes escogidos al azar para profundizar en otras variables como: frecuencia de síntomas y signos, ocupación y hacinamiento. Fue estudiada la causa del brote por cultivo virológico y reacciones serológicas de un grupo de pacientes; se identificó el virus Coxsackie A 24 como el agente causal de la epidemia. La tasa de ataque fue de 271,5 x 10 000 habitantes con la mayor afectación en el grupo de 15-29 años; el sexo femenino fue el de mayor participación porcentual y el hacinamiento estuvo presente en una proporción significativa de los pacientes afectados
Subject(s)
Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Conjunctivitis, Acute Hemorrhagic/epidemiology , Conjunctivitis, Acute Hemorrhagic/etiology , Disease Outbreaks , NicaraguaABSTRACT
An epidemic of acute conjunctivitis occurred in Delhi during July-September 1986. The clinical presentation in total of 350 patients were characteristic of acute haemorrhagic conjunctivitis (AHC). Bacterial cultures from conjunctival swabs were sterile in 85 out of 105 (80%) patients, virus cultures in Vero and HeLa cells were negative in 30 patients. However, conjunctival scrapes from 20/30 (66.7%) patients showed specific cytoplasmic fluorescence with enterovirus 70 (EV 70) antiserum, suggesting EV 70 to be the etiologic agent of the epidemic.
Subject(s)
Adolescent , Adult , Child , Child, Preschool , Conjunctivitis, Acute Hemorrhagic/epidemiology , Disease Outbreaks , Female , Humans , India/epidemiology , Infant , Male , Middle AgedABSTRACT
Coxsackie virus A 24 variant (CA24v) was found to be the etiological agent of an epidemic of acute haemorrhagic conjunctivitis (AHC) in Vellore during the months of October and November in 1986. CA24v was isolated in 21 of 25 acutely ill patients. In addition, seroconversion was seen in 11 of the 16 patients from whom paired sera were collected.
Subject(s)
Animals , Cell Line , Conjunctiva/microbiology , Conjunctivitis, Acute Hemorrhagic/epidemiology , Disease Outbreaks , Enterovirus/isolation & purification , Humans , India/epidemiology , MiceABSTRACT
Informaçöes de natureza epidemiológica, clínica e laboratorial sobre o segundo surto de conjuntivite hemorrágica aguda (CHA) ocorrido no período de três anos na cidade de Belém, Pará, Brasil, durante os meses de janeiro a abril de 1984. Foram atendidos 126 pacientes de ambos os sexos e colhidos especímes da conjuntiva, orofaringe e soro. Em 92 pares de soro foram realizados testes de neutralizaçäo para o enterovírus 70 (EV70) e fixaçäo do complemento para os adenovírus. Houve conversäo sorológica para o EV70 em 76,1% da amostra (70 pares). Näo foram constatadas evidências de comprometimento neurológico em pacientes de conjuntivite, durante ou após o surto